Citrus P. E.
Part Used: fruit (immature)
Synepherine is the main active compound found in the fruit of Citrus aurantium, which is effective in providing the energy boost (caloric expenditure) , aiding the expulsion of wind, warming the stomach, improving the appetite, and increasing metabolic rate. Citrus aurantium is theorized to stimulate fat metabolism without the negative cardiovascular side effects experienced by some people using Ma Huang. It is also a mild aromatic expectorant, a nervine and a laxation for constipation.
The most likely explanation for weight loss effects attributed to citrus aurantium supplements is the amphetamine-like effects of the alkaloids. Although this effect is likely to be somewhat less dramatic than effects induced by Ma Huang (ephedra alkaloids) , users can expect variable effects including enhanced caloric expenditure, reduced appetite and heightened feelings of energy, all of which are likely to result in weight loss. A recent study conducted in dogs also suggests that synephrine can increase metabolic rate in a specific type of fat tissue known as Brown Adipose Tissue (BAT) .
Since synephrine and several other compounds found in zhi shi are structurally similar to ephedrine and act as stimulants to specific adrenergic receptors (beta-3, but not beta-1, beta-2 or alpha-1) , zhi shi does not appear to have the same negative central nervous effects of Ma Huang (ephedra) , which stimulates all beta-adrenergic receptors
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