Artemisinin P.E

Physical properties: Clear needle-like crystal; M. P.:156-157 ; [ ] 17 D: +66.3 degree (C=1.64, chloroform) [1] ; IR (KBr, max) cm-1:1745,831,881,1115; NMR (CCl4):0.93(3H, J=6,14-CH3, doublet),1.06 (3H, J=6,13-CH3, doublet),1.36 (3H,15-CH3, singlet),3.08-3.44 (11-H, multiplet); 1.06 collapses to singlet upon radiation; 5.68 (7-H, singlet); 13 CNMR (CHCl3):12,19,23 (quaterplet,14,13,15-CH3),25,25.1,37,35.5(triplet,4,3,10,9-CH2),32.5,33,45,50,93.5 (doublet,2,5,1,11,7-CH),79.5,105,172 (singlet,6,8-c,12-c=0). No bouble bonds. No UV absoption.

Plant Source: Artemisia annua L. Leaves [1-4].

Functions and Applications: According to over 2000 clinical case studies, when used for the treatment of tertian fever, it is better than chloroquine in terms of time to suppress the pathogen. No adverse effect in clinical cases. Esp. Useful for the treatment of cases resistant to chloroquine. However, the short term recurrance rate is higher than chloroquine.

Dosage: According to large amount of clinical study, for the treatment of malaria, use intramuscular injections of 0.3g each time each day for three days, for a total amount of 0.9 -1.2g ; double first dose for severe case.

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